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SUMMARY:Keeping in  contact during collective cell migration -  Etienne-Ma
 nneville\, S (Institut Pasteur - CNRS)
DTSTART:20151119T160000Z
DTEND:20151119T170000Z
UID:TALK62626@talks.cam.ac.uk
CONTACT:42080
DESCRIPTION:Collective cell migration is essential during development as w
 ell as in adult organisms where it participates\, for instance\, in tissue
  renewal\, wound healing or cancer invasion and metastasis. As cells migra
 te collectively\, intercellular junctions maintain the integrity of the ce
 ll monolayer while allowing differential movement and rearrangements of ad
 jacent cells. In astrocytes\, intercellular contacts are mainly formed by 
 N-cadherin-mediated adherens junctions. Downregulation of N-cadherin is fr
 equently observed in astrocyte derived tumors\, gliomas and promotes singl
 e cell migration while perturbing cell polarity and increasing cell veloci
 ty. \n\nTo understand how cells can maintain stable intercellular junction
 s and simultaneously rearrange them to accommodate cellular displacement\,
  we have investigated cadherin dynamics during astrocyte collective migrat
 ion. We show adherens junctions undergo a continuous retrograde movement c
 ompensated by a polarized recycling of cadherin from the rear to the leadi
 ng edge. Such dynamics allows the cells to maintain stable contacts while 
 permitting changes of cellular interactions. In glioma cells\, N-cadherin 
 dynamics and consequently the maintenance of cell-cell contacts are pertur
 bed leading to loss of cell polarity and to increased migration.  \n\n
LOCATION:Seminar Room 2\, Newton Institute Gatehouse
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