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SUMMARY:New discoveries about ageing in C. elegans - Prof David Gems\, Ins
 titute of Healthy Ageing\, University College London
DTSTART:20160217T160000Z
DTEND:20160217T170000Z
UID:TALK62649@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:The disease syndrome that is ageing is the main cause of serio
 us illness and death in the world today\, but its underlying etiologies re
 main poorly understood. An influential theory has it that ageing is the re
 sult of an accumulation of molecular damage\, caused in particular by reac
 tive oxygen species (ROS) produced by mitochondria. This theory also predi
 cts that processes that protect against oxidative damage (involving detoxi
 fication\, repair and turnover) protect against ageing and increase lifesp
 an. However\, recent tests of the oxidative damage theory\, some using the
  short-lived nematode worm Caenorhabditis elegans\, have often failed to s
 upport the theory\, motivating consideration of other models. One recent t
 heory\, developed by M.V. Blagosklonny\, proposes that ageing is caused by
  the non-adaptive running on in later life of developmental and reproducti
 ve programmes. These ideas draw on G.C. Williams’s antagonistic pleiotro
 py theory and propose that late-life gene action causes development of pat
 hologies of ageing rather than\, as previously supposed\, system breakdown
 . We have been testing these ideas in C. elegans\, and find them surprisin
 gly well supported. They have enabled identification of etiologies of seve
 ral pathologies of C. elegans ageing\, and generated new insights into the
  broader nature of ageing. 
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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