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SUMMARY:Droplet-Based Microfluidics: High-Throughput Experimentation One D
 rop at a Time - Prof. Andrew J. deMello\, Professor of Biochemical Enginee
 ring Institute for Chemical and Bioengineering\, Institute for Chemical an
 d Bioengineering\, ETH Zürich\, Vladimir-Prelog-Weg 1\, 8093\, Zürich\, 
 Switzerland
DTSTART:20160129T140000Z
DTEND:20160129T150000Z
UID:TALK62654@talks.cam.ac.uk
CONTACT:Dr. Hernandez-Ainsa
DESCRIPTION:The past 25 years have seen considerable progress in the devel
 opment of microfabricated systems for use in the chemical and biological s
 ciences. Interest in microfluidic technology has driven by concomitant adv
 ances in the areas of genomics\, proteomics\, drug discovery\, high-throug
 hput screening and diagnostics\, with a clearly defined need to perform ra
 pid measurements on small sample volumes. At a basic level\, microfluidic 
 activities have been stimulated by the fact that physical processes can be
  more easily controlled when instrumental dimensions are reduced to the mi
 cron scale.1 The relevance of such technology is significant and character
 ized by a range of features that accompany system miniaturization. Such fe
 atures include the ability to process small volumes of fluid\, enhanced an
 alytical performance\, reduced instrumental footprints\, low unit costs\, 
 facile integration of functional components within monolithic substrates a
 nd the capacity to exploit atypical fluid behaviour to control chemical an
 d biological entities in both time and space. \n\nMy lecture will discuss 
 recent studies that are focused on exploiting the spontaneous formation of
  droplets in microfluidic systems to perform a variety of analytical proce
 sses. \n\nDroplet-based microfluidic systems allow the generation and mani
 pulation of discrete droplets contained within an immiscible continuous ph
 ase.2 They leverage immiscibility to create discrete volumes that reside a
 nd move within a continuous flow. Significantly\, such segmented-flows all
 ow for the production of monodisperse droplets at rates in excess of tens 
 of KHz and independent control of each droplet in terms of size\, position
  and chemical makeup. Moreover\, the use of droplets in complex chemical a
 nd biological processing relies on the ability to perform a range of integ
 rated\, unit operations in high- throughput. Such operations include dropl
 et generation\, droplet merging/fusion\, droplet sorting\, droplet splitti
 ng\, droplet dilution\, droplet storage and droplet sampling.3-4 I will pr
 ovide examples of how droplet-based microfluidic systems can be used to pe
 rform a range of experiments including nanomaterial synthesis\,5 cell-base
 d assays6 and DNA amplification.7 \n\n\n[1]	A.J. deMello\, Nature\, 442 (2
 006) 394-402. 
\n[2]	X. Casadevall-i-Solvas & A.J. deMello\, Chemical Co
 mmunications\, 47 (2011) 1936–1942. [3]	X. Niu\, S. Gulati\, J.B. Edel &
  A.J. deMello\, Lab Chip\, 8 (2008) 1837–1841. 
\n[4]	X.Niu\, F. Giele
 n\, J.B. Edel & A.J. deMello\, Nature Chemistry\, 3 (2011) 437-442. 
\n[
 5]	I. Lignos et al.\, Small\, 11 (2015) 4009–4017\n[6]	Soongwon Cho et a
 l.\, Analytical Chemistry\, 85 (2013) 8866–8872.\n[7]	Yolanda Schaerli e
 t al.\, Analytical Chemistry\, 81 (2009) 302-306.\n
LOCATION:Pippard Lecture Theater
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