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SUMMARY:Discrete and continuous modelling of cell mechanics: from adhesion
  to migration - Sanchez Rua\, T (Centro Universitario de la Defensa de Zar
 agoza)
DTSTART:20151124T110000Z
DTEND:20151124T123000Z
UID:TALK62698@talks.cam.ac.uk
CONTACT:42080
DESCRIPTION:The talk is devoted to two different approaches to model and s
 imulate processes occurring during cell migration. Firstly\, a discrete co
 mputational model in 3D is presented to simulate the formation of cell-mat
 rix adhesions on a single 3D matrix fibre. This model allows to analyse th
 e importance of the alignment between the matrix fibre and the cell protru
 sion on the size of the focal adhesions. Secondly\, a 1D multi-physics mod
 el of fluid-structure interaction to simulate the behaviour of a cell conf
 ined in a complex microfluidics device is introduced. Cells are modelled a
 s a poroelastic material following recent experimental evidences whereas t
 he fluid is modelled by using the Poiseuille equation\, considering it as 
 a laminar incompressible Newtonian fluid.\n
LOCATION:Seminar Room 2\, Newton Institute Gatehouse
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