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SUMMARY:&quot\;Plastic Transcriptomes and Proteomes at Synapses&quot\; - E
 rin Schuman\, Max Planck Institute for Brain Research
DTSTART:20160125T163000Z
DTEND:20160125T180000Z
UID:TALK62798@talks.cam.ac.uk
CONTACT:Lyn Dakin
DESCRIPTION:“Protein synthesis is a dynamic process that tunes the cellu
 lar proteome in response to internal and external demands. Metabolic label
 ing approaches identify the general proteomic response but cannot visualiz
 e specific newly synthesized proteins within cells. Here we describe a tec
 hnique that couples noncanonical amino acid tagging or puromycylation with
  the proximity ligation assay to visualize specific newly synthesized prot
 eins and monitor their origin\, redistribution and turnover in situ.”\n\
 n"The elaborate morphology of neurons together with the information proces
 sing that occurs in remote dendritic and axonal compartments makes the use
  of decentralized cell biological machines necessary. Recent years have wi
 tnessed a revolution in our understanding of signaling in neuronal compart
 ments and the manifold functions of a variety of RNA molecules that regula
 te protein translation and other cellular functions. Here we discuss the v
 iew that mRNA localization and RNA-regulated and localized translation und
 erlie many fundamental neuronal processes and highlight key issues for fut
 ure experiments."\n
LOCATION:The Hodgkin Huxley Seminar Room\, Department of Physiology Develo
 pment and Neuroscience
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