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SUMMARY:Record linkage for epidemiology of less common vascular diseases: 
 the first large-scale prospective study of aortic stenosis - Dr Benjamin C
 airns\, Nuffield Department of Population Health\, University of Oxford
DTSTART:20151216T140000Z
DTEND:20151216T150000Z
UID:TALK62856@talks.cam.ac.uk
CONTACT:Narinder Bansal
DESCRIPTION:Aortic valve stenosis (aortic stenosis) is an uncommon vascula
 r disease\, affecting 2-4% of adults >60 years of age. No medical treatmen
 ts are known to prevent or slow progression of the disease\, and valve rep
 lacement is the only option in severe\, symptomatic cases\, which otherwis
 e have a 1-year mortality of up to 50%. The pathophysiology of aortic sten
 osis shares some similarities with coronary atherosclerosis\, but because 
 it is relatively uncommon\, studies of risk factors for aortic stenosis ha
 ve been hampered by small numbers. This is changing\, however\, with the i
 ncreased availability of routinely-collected healthcare data for record li
 nkage to large prospective studies. I will discuss the example of the Mill
 ion Women Study\, which by linkage to UK hospital admissions data includes
  over 4000 cases of aortic stenosis and 1600 aortic valve replacements\, a
 s well as over 70\,000 cases of coronary heart disease. These data improve
  on sample sizes of previous studies by an order of magnitude. I will pres
 ent results of analyses of risk of aortic stenosis in relation to known va
 scular disease risk factors. Given the failure of lipid-lowering therapies
  to slow progression of the disease in recent clinical trials\, these find
 ings provide new hope that there are modifiable risk factors for severe ao
 rtic stenosis.
LOCATION:Thomas Strangeways Room\, Strangeways Research Laboratory
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