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SUMMARY:Pressure-driven occlusive flow of a confined red blood cell - Dr T
 hierry Savin\, CUED
DTSTART:20160115T140000Z
DTEND:20160115T150000Z
UID:TALK62986@talks.cam.ac.uk
CONTACT:Ms Helen Gardner
DESCRIPTION:When red blood cells (RBCs) move through narrow capillaries in
  the microcirculation\, they deform as they flow. In pathophysiological pr
 ocesses such as sickle cell disease and malaria\, RBC motion and flow are 
 severely restricted. To understand this threshold of occlusion\, we used a
  combination of experiments and theory to study the motion of a single swo
 llen RBC through a narrow glass capillary of varying inner diameter. By tr
 acking the movement of the squeezed cell as it is driven by a controlled p
 ressure drop\, we measured the RBC velocity as a function of the pressure 
 gradient as well as the local capillary diameter\, and found that the effe
 ctive blood viscosity in this regime increases with both decreasing RBC ve
 locity and tube radius by following a power-law that depends upon the leng
 th of the confined cell. Our observations are consistent with a simple ela
 sto-hydrodynamic model and highlight the role of lateral confinement in th
 e occluded pressure-driven slow flow of soft confined objects.
LOCATION:Oatley Seminar Room\, Department of Engineering
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