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SUMMARY:How cryo-EM is revolutionising structural biology - Dr. Sjors Sche
 res\, MRC Laboratory of Molecular Biology\, Cambridge
DTSTART:20160113T103000Z
DTEND:20160113T113000Z
UID:TALK63342@talks.cam.ac.uk
CONTACT:Jerome Charmet
DESCRIPTION:Recent advances in direct-electron detectors and advanced imag
 e processing algorithms have resulted in cryo-EM structure determination t
 o near-atomic resolution for a wide range of macromolecular complexes. I w
 ill discuss these advances and illustrate their potential by presenting ou
 r results on gamma-secretase. This intra-membrane protease cleaves many su
 bstrates\, and is perhaps best known for producing amyloid-beta peptides\,
  abundant deposits of which in the brain are a defining characteristic of 
 Alzheimer's disease.\n
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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