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SUMMARY:Studying membrane bioactivity with super-resolution optical micros
 copy - Professor Christian Eggeling\, Weatherall Institute of Molecular Me
 dicine\, Oxford
DTSTART:20160405T150000Z
DTEND:20160405T160000Z
UID:TALK63379@talks.cam.ac.uk
CONTACT:Alice Wood
DESCRIPTION:Molecular interactions in the plasma membrane of living cells 
 are key in cellular signalling. Protein-protein or protein-lipid complexes
 \, the formation of lipid nanodomains (often denoted “rafts”)\, or dif
 fusional restrictions by the cortical cytoskeleton are considered to play 
 a functional part in a whole range of membrane-associated processes. The d
 irect and non-invasive observation of such interactions in living cells is
  often impeded by principle limitations of conventional far-field optical 
 microscopes\, specifically with respect to limited spatio-temporal resolut
 ion. \n\nWe present how novel details of molecular membrane dynamics can b
 e obtained by using advanced microscopy approaches such as the combination
  of super-resolution STED microscopy with fluorescence correlation spectro
 scopy (STED-FCS). We will focus on new insights into the lipid “raft” 
 theory\, and on the role of plasma membrane and cytoskeleton organization 
 in the triggering of immune cells\, specifically during T-cell activation
LOCATION:Pfizer LT
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