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SUMMARY:Between life and death: A dual function for the mitochondrial F-AT
 P synthase - Professor Paolo Bernardi\, University of Padova\, Italy
DTSTART:20160202T150000Z
DTEND:20160202T160000Z
UID:TALK63388@talks.cam.ac.uk
CONTACT:Penny Peck
DESCRIPTION:The permeability transition (PT) denotes a calcium-dependent p
 ermeability increase of the inner membrane of mitochondria to solutes with
  molecular masses up to about 1\,500 Da. It is mediated by a channel\, the
  permeability transition pore (PTP)\, whose nature remained a mystery for 
 60 years. We have recently shown that under conditions of oxidative stress
  the F-ATP synthases of mammals\, yeast and drosophila can be turned into 
 calcium-activated channels whose electrophysiological properties match tho
 se of the corresponding PTPs. I will discuss channel formation by F-ATP sy
 nthases and report on the identification\, optimization and testing of nov
 el high-affinity inhibitors. 
LOCATION:Sackler Lecture Theatre (Level 7) Wellcome Trust/MRC Building\, A
 ddenbrooke's Site
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