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SUMMARY:Defining cell states and regulatory networks by single cell expres
 sion profiling - Professor Bertie Gottgens
DTSTART:20160113T140000Z
DTEND:20160113T150000Z
UID:TALK63492@talks.cam.ac.uk
CONTACT:Emily Boyd
DESCRIPTION:Work in the Gottgens lab has recently utilised single cell exp
 ression profiling technology to study the emergence of the first wave of h
 aematopoiesis in the developing embryo\, and used the expression data from
  nearly 4\,000 single cells to construct a transcriptional regulatory netw
 ork model that captures key aspects of early blood development.  In parall
 el work\, the group has used single cell expression profiling to study the
  cellular heterogeneity of the adult blood stem/progenitor compartment\, g
 aining new insights into the likely nature of long-term blood stem cells. 
 \n\nTaken together\, this work highlights (i) that single cell genomics is
  a promising technology to advance our knowledge of blood cell development
 \, and (ii) that advanced computational analysis is essential to optimise 
 extraction of new biological knowledge from such data.
LOCATION:MR4\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
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