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SUMMARY:Endothelial Cells and HIF transcription factors regulating lung pr
 e-disposition for metastatic events - Dr Cristina Branco\, PDN Cambridge
DTSTART:20160310T160000Z
DTEND:20160310T170000Z
UID:TALK63507@talks.cam.ac.uk
CONTACT:Sarah Harrison
DESCRIPTION:The vasculature\, as an extraordinarily versatile organ\, is n
 ot just the preferred transport system for most compounds and cells\, but 
 also has a broad and sophisticated ability to adjust to internal and exter
 nal cues\, to respond and produce signals\, recruit and interact different
 ly with different cell types\, and function both as a barrier and a select
 ive filter. The properties of blood capillaries are organ- and context-spe
 cific\, and the regulation of those functional differences are not yet ful
 ly understood or characterized\, even in pathological contexts. I am inter
 ested in studying tumor dispersion (metastatic disease) from the perspecti
 ve of the host physiological pre-disposition as opposed to the cancer aggr
 essiveness: patients diagnosed with the same cancer type at similar stage 
 often progress very differently\, and secondary cancer is the chief cause 
 of mortality. I have found that metabolism regulated by HIF transcription 
 factors in endothelial cells significantly affect the incidence of lung me
 tastases\, and will be discussing which parameters and environmental chall
 enges could contribute to alter organ-predisposition\, vascular compliance
 /resistance to circulating tumor cells\, and the circumstantial intricacie
 s of cell behavior that can help or hinder tumor dissemination to distant 
 sites.\n
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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