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SUMMARY:Towards the understanding of the genetic bases of complex adaptati
 ons in the human genome - Prof Jaume Bertanpetit\, Universitat Pompeu Fabr
 a\, Barcelona
DTSTART:20160203T163000Z
DTEND:20160203T173000Z
UID:TALK63957@talks.cam.ac.uk
CONTACT:Aurélien Mounier
DESCRIPTION:Evolutionary analysis at the genome level may detect the actio
 n of natural selection in genes and groups of genes\, which are linked to 
 phenotypes. For that\, it is necessary to understand the molecular pathway
 s of gene products. This analysis targets the molecular basis of complex a
 daptations. By comparing genomic data between species\, or different popul
 ations of the same species\, we can distinguish between selection at large
  or small scales\, allowing the detection of natural selection in the form
  of positive selection and purifying selection. One of the interesting evo
 lutionary challenges is to discover the genetic bases of adaptive phenotyp
 es\, but the greatest challenges are complex adaptations. In humans\, sele
 ction has not acted equally throughout evolutionary history: genes with hi
 gher numbers of interactions are more likely to have been targeted by rece
 nt positive selection during recent human evolution. Our results indicate 
 that the relationship between centrality and the impact of adaptive evolut
 ion depends to a high degree on the evolutionary time-scale. Most likely\,
  network adaptation occurs through intraspecific adaptive leaps affecting 
 key network genes\, followed by the fine-tuning of adaptations in less imp
 ortant network regions. These results reshape the profile of traditional e
 volutionary landscapes.
LOCATION:Seminar Room\, Henry Wellcome Building\, Division of Biological A
 nthropology\, Fitzwilliam Street\, Cambridge\, CB2 3QG
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