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SUMMARY:&quot\;The use of clonal stem cells in CNS disease models: what ca
 n we learn from stem cells?&quot\; - Dr Antal Nogradi\, University of Szeg
 ed\, Hungary
DTSTART:20160420T110000Z
DTEND:20160420T120000Z
UID:TALK63997@talks.cam.ac.uk
CONTACT:Shannon Tinley-Browne
DESCRIPTION:Injury to the CNS has a devastating effect on the patients\, l
 eaving the body with serious loss of motor and sensory functions.  Transpl
 antation of stem cells provides a successful experimental therapeutic stra
 tegy to treat these CNS disorders.\nClonal stem cells are reliably reprodu
 cible cells with constant features.  Their possible mechanism of action is
  based upon a) their neuroprotective effect\, b) their capacity to promote
  regeneration of injured axons by down-regulating the development of the n
 on-permissive glial environment and c) to a lesser extent replacement of l
 ost glial cells and neurons.  Indeed\, grafting a well characterised clona
 l stem cell line (NE-GFP-4C\, ATCC No. CRL-2926) into the injured spinal c
 ord results in functional and morphological improvement. Our data suggest 
 that undifferentiated clonal stem cells secrete a variety of cytokines and
  some of the neurotrophic factors for a limited period of time after trans
 plantation into the injured cord.  On the other hand\, some cells of graft
  origin appear to have been integrated into the injured cord\, especially 
 those that have differentiated towards a oligodendrocyte phenotype. The ad
 ministration of function-blocking antibodies via osmotic pumps along with 
 grafted stem cells nearly completely abolished the effect of stem cell gra
 fting\, suggesting a minor\, but not negligible role for the stem cell-der
 ived glial and neuronal cells in the functional improvement.  Similarly\, 
 transplantation of NE-GFP-4C stem cells into vitreous body of glaucomatous
  eyes in rats  rescued the retinal ganglion cells otherwise destined to di
 e.  The mechanism of action appears to be based upon similar signalling pa
 thways as in the case of injured spinal cord.   These data suggest that cl
 onal stem cells exert their effects via multiple mechanisms of action\, re
 sulting in considerably improved outcome after a severe experimental CNS i
 njury. \n
LOCATION:Brain Repair Centre\, Forvie Site\, Robinson Way
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