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SUMMARY:Understanding the neuronal control of ageing and proteostasis - Dr
 . Rebecca Taylor\, MRC Laboratory of Molecular Biology
DTSTART:20160203T103000Z
DTEND:20160203T113000Z
UID:TALK64247@talks.cam.ac.uk
CONTACT:Jerome Charmet
DESCRIPTION:Ageing is a process associated with tissue decline and the ons
 et of numerous diseases. Once thought to be a random process driven by acc
 umulated damage\, we now know that ageing and the onset of age-associated 
 disease can be influenced by both genetic and environmental factors. One c
 haracteristic of ageing is an accumulation of misfolded and aggregated pro
 teins\, which underlie many of the diseases associated with old age. These
  proteins accumulate as a result of an age-associated failure in the cellu
 lar stress responses that detect and clear damaged proteins. Focusing on t
 he endoplasmic reticulum unfolded protein response (UPR)\, we are interest
 ed in how stress responses can be manipulated to increase health and longe
 vity. In particular\, we have found that activating the UPR in the nervous
  system of C. elegans activates a novel signaling pathway that leads to st
 ress response activation in other tissues. We are now exploring the signal
 ing mechanisms that allow this stress response activation to be communicat
 ed between tissues\, and utilizing multiple approaches to understand how s
 ystemic stress response activation leads to increased health and longevity
 \, with a view to harnessing this pathway for disease treatment.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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