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SUMMARY:CRISPR/Cas9 – the good\, the bad and the ugly! - Dr Aisling Redm
 ond (CRUK CI)\, Dr Florian Merkle (Stem Cell Institute) &amp\; Dr Alasdair
  Russell (CRUK CI)
DTSTART:20160622T173000Z
DTEND:20160622T190000Z
UID:TALK64313@talks.cam.ac.uk
CONTACT:Mark Dunning
DESCRIPTION:The CRISPR/Cas9 genome editing technology is a very powerful t
 ool that is being used\nextensively in labs around the world. This adapted
  immunity system from bacteria works in a\nsimple way to cleave DNA. In it
 s original\, wild-type format\, CRISPR/Cas9 can create double\nstranded br
 eaks in DNA but the nuclease enzyme can also selectively cleave a single D
 NA\nstrand or bind to a specific region of interest. The most common use o
 f this technology is to\nreduce the level of a target protein by introduci
 ng a stop codon in the mRNA. However\,\nfurther uses in modifying epigenet
 ic features of DNA and introducing or deleting DNA\nsequences\, have also 
 been explored. Controversially\, CRISPR/Cas9 has been used to modify\nthe 
 genome of human tripronuclear zygotes and debates regarding the ethics of 
 this are\nongoing. In this masterclass\, the speakers will give an overvie
 w of the CRISPR/Cas9\ntechnology\, including its many uses and their exper
 iences of this system.\n
LOCATION:Postdoc Centre\, 16 Mill Lane
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