BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Rational design of protein aggregation - Prof. Frederic Rousseau\,
  VIB (Belgium)
DTSTART:20160210T103000Z
DTEND:20160210T113000Z
UID:TALK64352@talks.cam.ac.uk
CONTACT:Jerome Charmet
DESCRIPTION:Protein aggregation is in large part determined by the presenc
 e of aggregation-prone segments in a protein sequence and their relation w
 ith the native structure. During this presentation I will illustrate how t
 hese aggregation-determining sequences can be engineered to increase aggre
 gation resistance without affecting native protein structure. I will also 
 show how these sequences can be harnessed to induce specific aggregation-i
 nduced loss-of-function phenotypes in bacteria\, plants and mammalian cell
 s. Both inhibiting and inducing aggregation could lead to useful biotechno
 logical application. These exercises also inform on the evolutionary optio
 ns allowing folded proteins to adapt solubility and on the sequence-depend
 ence of protein aggregate toxicity.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
END:VEVENT
END:VCALENDAR