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SUMMARY:An In Silico High Throughput Screening Strategy to Identify Putati
 ve Disease Modifying Agents for Chronic Neurological Disorders - Professor
  Donald F. Weaver\, University of Toronto
DTSTART:20160302T141500Z
DTEND:20160302T151500Z
UID:TALK64353@talks.cam.ac.uk
CONTACT:Lisa Masters
DESCRIPTION:Neurology is sometimes referred to as the “diagnose and adio
 s” specialty\, referring to the dearth of “curative” disease modifyi
 ng drugs (DMDs) for the majority of major neurological disorders. Epilepsy
  and dementia are two of the most common neurological disorders. Although 
 “symptomatic” agents are available\, there are no DMDs for either of t
 hese disorders.  In an attempt to identify agents\, we created two in sili
 co libraries for high throughput screening: the first (11.8 million entrie
 s) consists of commercially available organic molecules\;   the second con
 sists of all molecules (MW<650 g/mol) endogenously occurring within the hu
 man central nervous system.  To identify agents as possible therapeutics f
 or epilepsy\, these libraries were screened for compounds capable of bindi
 ng to either the voltage gated sodium channel or the ligand gated GABA and
 /or NMDA channels.  To identify agents as possible therapeutics for protei
 n misfolding dementias\, these libraries were screened for compounds capab
 le of binding to one or both of the beta-amyloid and tau proteins – the 
 two primary peptides implicated in the proteopathic basis of Alzheimer’s
  disease and associated tauopathies.   
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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