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SUMMARY:The role of extrinsic and intrinsic factors in amyloid β peptide 
 aggregation - Prof. Sara S. Linse\, Lund University
DTSTART:20160217T103000Z
DTEND:20160217T113000Z
UID:TALK64453@talks.cam.ac.uk
CONTACT:Jerome Charmet
DESCRIPTION:Sequence variants and environmental factors are crucial molecu
 lar determinants of the aggregation rate and mechanism of amyloid-β pepti
 de (Aβ) implicated in Alzheimer's disease. We investigate these factors t
 hrough highly reproducible experiments and global kinetic analyses. Exampl
 es of sequence modifications we have studied are truncations and extension
 s\, as well as designed and disease-associated mutations. Examples of extr
 insic factors we have studied are salt\, pH\, inhibitors and body fluids. 
 Through these studies we learn not only about the role of each factor\, bu
 t the results obtained under perturbations provide new insights also into 
 the aggregation mechanism of the non-disturbed system. In several systems\
 , we have investigated the possible co-aggregation of peptide variants as 
 stimulated by the co-existence in humans of multiple Aβ sequence variants
 . Finally\, detailed knowledge of the aggregation mechanism has enabled a 
 search for cellular targets of transient oligomers on-pathway in the aggre
 gation process.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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