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SUMMARY:Sequencing Ebola virus in an insect filled tent\; how real-time ne
 xt generation sequencing aided the epidemic response. - Professor Ian Good
 fellow (Division of Virology\, Department of Pathology) and Dr Matt Cotten
  (Sanger Centre)
DTSTART:20160302T183000Z
DTEND:20160302T200000Z
UID:TALK64496@talks.cam.ac.uk
CONTACT:Mark Dunning
DESCRIPTION:The largest known outbreak of Ebola virus disease (EVD) in Wes
 t Africa is now being brought under control. A crucial tool in stopping th
 e virus was rapid epidemiological tracing of cases and contacts. Phylogene
 tics based on Ebola virus (EBOV) genome sequences provided a powerful tool
  for tracking the virus through the outbreak. To help in the effort\, a ne
 xt generation sequencing facility was established in a tent at an Ebola Tr
 eatment Centre in Sierra Leone  with full virus genomes obtained from diag
 nostic samples within 24 hours. The effort generated 554 EBOV genomes from
  EVD cases across Sierra Leone\, >1/3 of the total sequence data available
  from the outbreak. These data enabled phylogenetic tracking of new EVD ca
 ses and provided evidence for unconventional transmission chains involving
  semen and breast milk body fluids. The coupling of viral phylogenetics wi
 th infection control management should therefore form a major part of outb
 reak emergency responses.
LOCATION:Postdoc Centre\, 16 Mill Lane
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