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SUMMARY:Exploiting single-cell fluctuations - Johan Paulsson (Harvard Univ
 ersity)
DTSTART:20160120T090000Z
DTEND:20160120T094500Z
UID:TALK64653@talks.cam.ac.uk
CONTACT:INI IT
DESCRIPTION:All intracellular processes involve components present in low 
 numbers\, creating spontaneous fluctuations that in turn can enslave the c
 omponents present in high numbers. The mechanisms often appear complex\, w
 ith reaction rates that depend nonlinearly on concentrations\, indirect fe
 edback loops\, and distributed delays. Most systems are also sparsely char
 acterized\, with a few steps known in detail but many important interactio
 ns not even identified. In the first half of the talk\, I will discuss mat
 hematical approaches that exploit natural fluctuations to more reliably an
 alyze data and to make predictions about what complex biological networks 
 cannot do. In the second half I will discuss some of our recent experiment
 al results on the role of fluctuations in cells\, e.g. in the segregation 
 of mitochondria\, oscillations of synthetic genetic networks\, bacterial c
 ell fate decisions\, and DNA repair.
LOCATION:Seminar Room 1\, Newton Institute
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