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SUMMARY:Tracing the cellular basis of epidermal maintenance and cancer - B
 en Simons (University of Cambridge)
DTSTART:20160120T141500Z
DTEND:20160120T150000Z
UID:TALK64659@talks.cam.ac.uk
CONTACT:INI IT
DESCRIPTION:In adult\, tissues are maintained and repaired by stem cells\,
  which divide and differentiate to generate more specialized progeny. The 
 mechanisms that control the balance between proliferation and differentiat
 ion promise fundamental insights into the origin and design of multi-cellu
 lar organisms. Using epidermis as a model system\, we show how the combina
 tion of genetic lineage tracing assays in transgenic mouse models with sim
 ple ideas from non-equilibrium statistical physics provide a quantitative 
 platform to resolve the stochastic fate behaviour of stem cells and their 
 progeny in both healthy and diseased states. Furthermore\, we describe how
  these methods can be adapted to address exome deep-sequening data\, provi
 ding a new and general method to resolve the pattern of normal stem cell f
 ate\, and detect and characterize the mutational signature of rare field t
 ransformations in human tissues\, with implications for the early detectio
 n of preneoplasia.
LOCATION:Seminar Room 1\, Newton Institute
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