BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Mapping tumours in 4D – Spatially and temporally resolved genomi
 cs - Dario Bressan 
DTSTART:20160225T131000Z
DTEND:20160225T140000Z
UID:TALK64736@talks.cam.ac.uk
CONTACT:Evros Loukaides
DESCRIPTION:Tumours don’t exist in isolation. Rather\, they are embedded
  in a living organism and constantly interact with their surroundings. Blo
 od vessels\, healthy neighbouring tissues\, immune system\, and many other
  local factors all play an important role in the progress of a disease. To
  study cancer effectively\, we must study it in its own context\, in situ.
 \n High-throughput sequencing – a method to identify the sequence of mo
 st of the DNA and RNA molecules in cells - is incredibly powerful in givi
 ng us clues to understand how cells work\, but so far it could only be don
 e on a homogenised sample\, with a complete loss of spatial information.\n
  In our research group\, we are trying to develop a technology to use micr
 oscope slides as a support for sequencing\, getting information on the gen
 etic content on each cell preserving their position and structure. Further
 more\, we are trying to combine this technology with a new type of 3d micr
 oscopy and with lineage tracing (a technique to find the “family tree”
  of a cell) to produce a complete tri-dimensional map of the tissue\, and 
 reconstruct how it evolved over time.\n Our aim is to be able to obtain a 
 complete molecular fingerprinting of each cell in a tumour (or other healt
 hy tissues)\, which would reveal many new insights on how the disease pro
 gresses and how it could be treated. In my talk\, I’ll describe how we p
 lan to get there\, and describe some of our preliminary results.\n 
LOCATION:The Richard King Room\, Darwin College
END:VEVENT
END:VCALENDAR