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SUMMARY:Using C. elegans to learn principles of eukaryotic chromatin regul
 ation - Julie Ahringer\, The Gurdon Institute\, University of Cambridge
DTSTART:20160302T140000Z
DTEND:20160302T150000Z
UID:TALK64742@talks.cam.ac.uk
CONTACT:Emily Boyd
DESCRIPTION:All nuclear events take place in the context of chromatin\, th
 e organization of genomic DNA with histones and hundreds of associated pro
 teins and RNAs. Regulation of the composition and structure of chromatin c
 ontrols transcription and other nuclear processes\, and is important for c
 ell fate decisions\, the expression of cell identity\, the maintenance of 
 pluripotency\, and the transformation to cancer.  However\, our knowledge 
 of chromatin structure and function is still at a basic level. We use C. e
 legans to address these questions because it has a complement of core chro
 matin factors very similar to that of humans\, a small well-annotated geno
 me (30x smaller than human)\, RNAi for loss of function studies\, and well
 -characterised cell fates.  I will discuss our work on transcription regul
 ation and genome organization\, such as properties and activities of promo
 ters and enhancers\, and principles of genome organization inferred from c
 hromatin state mapping.
LOCATION:MR4\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
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