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SUMMARY:[TMS Symposium] Tissue mechanics in early brain development - Joy 
 Thompson
DTSTART:20160221T101500Z
DTEND:20160221T104500Z
UID:TALK64754@talks.cam.ac.uk
CONTACT:Jason Kwong
DESCRIPTION:Neuronal growth is essential for nervous system development an
 d is also required for regeneration after\nnervous tissue injury. Recent i
 n vitro studies suggest that neuronal growth can also be regulated by\nmec
 hanical properties of the substrate\; however\, the role of mechanical cue
 s in axon pathfinding in\nvivo\, and the spatiotemporal dynamics of tissue
  mechanics during early nervous system development\,\nare still largely un
 known. I am investigating the role of tissue stiffness in axon guidance wi
 thin the early\nembryo\, using the Xenopus laevis optic tract as a model s
 ystem. I find that the path of optic tract\ngrowth is correlated with stif
 fness gradients in the living brain\, before growth stalls after reaching 
 the\nsofter region. This is consistent with a role for substrate mechanics
  in axon pathfinding.\n
LOCATION:Winstanley Lecture Theatre\, Trinity College
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