BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Circulating tumour cells: a model from breast cancer to bone metas
 tasis - Dr Gianluca Ascolani
DTSTART:20160224T140000Z
DTEND:20160224T150000Z
UID:TALK64766@talks.cam.ac.uk
CONTACT:Emily Boyd
DESCRIPTION:Ductal carcinoma is one of the most common cancers among women
 \, and the main cause of death is\nthe formation of metastases. The develo
 pment of metastases is caused by cancer cells that migrate\nfrom the prima
 ry tumour site (the mammary duct) through the blood vessels and extravasat
 ing\, they\ninitiate metastasis (preferentially in the bone tissue). We pr
 esent a multi-compartment model that aims at elucidating the effects of th
 e TGF- and the concomitant therapies in the three microenvironments:\nmam
 mary duct\, circulatory system and bone niche. Starting from the gene expr
 ession profile of circulating tumour cells and clinical data\, we use the 
 model in order to predict the patient-specific survival and to explain the
  role of circulating tumour cells in the progression of the disease provid
 ing a quantitative measure of the cell driver mutations needed for invadin
 g the bone tissue.
LOCATION:MR4\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
END:VEVENT
END:VCALENDAR