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SUMMARY:Rapid adaptation and the predictability of evolution - Richar Nehe
 r\, Max Planck Institute for Developmental Biology
DTSTART:20160525T150000Z
DTEND:20160525T160000Z
UID:TALK64914@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Evolution is simple if adaptive mutations appear one at a time
 . However\,\nin large microbial populations many mutations arise simultane
 ously\nresulting in a complex dynamics of competing variants. I will discu
 ss\nrecent insight into universal properties of such rapidly adapting\npop
 ulations and compare model predictions to whole genome deep\nsequencing da
 ta of HIV-1 populations at many consecutive time points.\nGenetic diversit
 y data can further be used to infer fitness of\nindividuals in a populatio
 n sample and predict successful genotypes. We\nvalidate these prediction u
 sing historical influenza virus sequence\ndata. Successful predictions of 
 the composition of future influenza\nvirus population could guide strain s
 election for seasonal influenza\nvaccines.\n
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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