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SUMMARY:Why are tumours dependent on the MYC oncoprotein? - Dan Lu\, Gerar
 d Evan Lab\, Department of Biochemistry
DTSTART:20160318T140000Z
DTEND:20160318T150000Z
UID:TALK64932@talks.cam.ac.uk
CONTACT:14813
DESCRIPTION:Description: Cancers arise when cell-signalling pathways\, whi
 ch are normally tightly regulated\, become disrupted. Tumours subsequently
  become dependent on the expression of certain proteins\, sometimes referr
 ed to as “oncogene addiction”. Identification of these tumour-specific
  vulnerabilities\, absent from normal cells\, provides a therapeutic windo
 w. In this talk\, I provide molecular rationales on how inhibition of the 
 MYC oncoprotein\, deregulated in most if not all human cancers\, leads to 
 the regression of a multitude of tumour types (including lung\, pancreas a
 nd mammary).\n
LOCATION:Department of Biochemistry - Sanger Building\, Seminar Room
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