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SUMMARY:Calcium Signalling Dynamics in the Killer T-Cell Attack - Nele Die
 ckmann – PhD Student\, Cambridge Institute for Medical Research\, Wolfso
 n College
DTSTART:20160304T151500Z
DTEND:20160304T152500Z
UID:TALK64990@talks.cam.ac.uk
CONTACT:Francisco Orozco
DESCRIPTION:Cytotoxic T-lymphocytes (CTLs) are white blood cells in the hu
 man immune system that eliminate virally infected and tumourigenic cells. 
 CTLs kill by delivering a cocktail of toxic substances that rapidly trigge
 rs a self-destruction programme (apoptosis) in the target cell. The releas
 e of these pro-apoptotic factors must be tightly controlled and only occur
 s once a well-sealed interface known as the ‘Immune Synapse’ is establ
 ished between T-cell and its target. The study of several immunodeficiency
  conditions identified key parts of the protein machinery that is essentia
 l for CTL killing. It is furthermore known that calcium signalling is cruc
 ial to trigger and sustain a successful CTL attack and it has been suggest
 ed that global and local calcium fluxes in the T-cell drive multiple steps
  in this attack. However\, it remains unclear what the exact timescales an
 d magnitudes of calcium fluxes are and whether these might be changed when
  killing is impaired through genetic mutations or pharmacological inhibiti
 on. Using high speed live-cell imaging I followed the CTL attack on target
  cells in 4D to monitor and compare global calcium signals in healthy and 
 mutant CTL.
LOCATION:Lee Hall\, Wolfson College
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