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SUMMARY:Cellular signalling in T cells is captured by a tractable modular 
 phenotypic model - Omer Dushek ()
DTSTART:20160406T080000Z
DTEND:20160406T084500Z
UID:TALK65327@talks.cam.ac.uk
CONTACT:INI IT
DESCRIPTION:T cells initiate adaptive immune responses when their T cell a
 ntigen receptors (TCRs) recognise antigenic peptides bound to major histoc
 ompatibility complexes (pMHC). The binding of pMHC ligands to the TCR can 
 trigger a large signal transduction cascade leading to T cell activation\,
  as measured by the secretion effector cytokines/chemokines. Although the 
 signalling proteins involved have been identified\, it is still not unders
 tood how the cellular signalling network that they form converts the dose 
 and affinity of pMHC into T cell activation. Here we use a holistic method
  to infer the signalling architecture from T cell activation data generate
 d by stimulating T cells with a 100\,000-fold variation in pMHC affinity/d
 ose. We observe bell-shape dose-response curves and a different optimal pM
 HC affinity at different pMHC doses. We show that this can be explained by
  a unique\, tractable\, and modular phenotypic model of signalling that in
 cludes kinetic proofreading with limited sign alling coupled to incoherent
  feedforward but not negative feedback. The work provides a complementary 
 approach for studying cellular signalling that does not require full detai
 ls of biochemical pathways.<br><br>Related Links<ul><li><a target="_blank"
  rel="nofollow">http://www.path.ox.ac.uk/content/omer-dushek</a>&nbsp\;- H
 ome page</li></ul>
LOCATION:Seminar Room 1\, Newton Institute
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