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SUMMARY:Fundamental limits to transcriptional regulatory control - Pieter 
 Rein ten Wolde ()
DTSTART:20160407T080000Z
DTEND:20160407T084500Z
UID:TALK65366@talks.cam.ac.uk
CONTACT:INI IT
DESCRIPTION:Gene expression is typically regulated by gene regulatory prot
 eins that bind to the DNA. Experiments have shown that these proteins find
  their DNA target site via a combination of 3D diffusion in the cytoplasm 
 and 1D diffusion along the DNA. This stochastic transport sets a fundament
 al limit on the precision of gene regulation. We derive this limit analyti
 cally and show by particle-based GFRD simulations that our expression is h
 ighly accurate under biologically relevant conditions.
LOCATION:Seminar Room 1\, Newton Institute
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