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SUMMARY:A stochastic story of two receptors and two ligands - Carmen Molin
 a-Paris (University of Leeds)
DTSTART:20160407T130000Z
DTEND:20160407T134500Z
UID:TALK65370@talks.cam.ac.uk
CONTACT:INI IT
DESCRIPTION:In this talk\, I will introduce the role of the co-receptors  
 CD28 and CTLA-4 in the immune system. Both CD28 and CTLA-4 molecules are e
 xpressed on the membrane of T cells and can bind CD80 and  CD86 ligand mol
 ecules\, expressed on the membrane of antigen presenting cells. Classical 
 immunology has identified CD28 co-receptor as enhancing the signal receive
 d by T cells from their T cell receptors (TCRs)\, and CTLA-4 as suppressin
 g TCR signals. New experimental work is supporting a different role for th
 e CTLA-4 molecule.  In this talk\, I will describe work in progress by our
  group\, to model as&nbsp\; a multi-variate stochastic process the system 
 of two receptors and two ligands.&nbsp\;
LOCATION:Seminar Room 1\, Newton Institute
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