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SUMMARY:Subtle is the noise\, but malicious it is not: dynamic exploits of
  intracellular noise - Mustafa Khammash (ETH Zürich)
DTSTART:20160407T150000Z
DTEND:20160407T154500Z
UID:TALK65373@talks.cam.ac.uk
CONTACT:INI IT
DESCRIPTION:<span>Co-authors: Ankit Gupta (ETH Z&uuml\;rich)\, Corentin Br
 iat (ETH Z&uuml\;rich)<br></span><span><br>Using homeostasic regulation an
 d oscillatory entrainment as examples\, I demonstrate how novel and benefi
 cial functional features can emerge from exquisite interactions between in
 tracellular noise and network dynamics. While it is well appreciated that 
 negative feedback can be used to achieve homeostasis when networks behave 
 deterministically\, the effect of noise on their regulatory function is no
 t understood. Combining ideas from probability and control theory\, we hav
 e developed a theoretical framework for biological regulation that explici
 tly takes into account intracellular noise. Using this framework\, I will 
 introduce a new regulatory motif that exploits stochastic noise\, using it
  to achieve precise regulation and perfect adaptation in scenarios where s
 imilar deterministic regulation fails. Next I propose a novel role of intr
 acellular noise in the entrainment of decoupled biological oscillators. I 
 will show that while intrinsic noise may inhibit oscillatory activity in i
 nd ividual oscillators\, it can actually induce the entrainment of a popul
 ation of such oscillators. Thus in both regulation and oscillatory entrain
 ment\, beneficial dynamic features exist not just in spite of the noise\, 
 but rather because of it.</span>
LOCATION:Seminar Room 1\, Newton Institute
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