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SUMMARY:Sustainable Manufacture of Fine Chemicals and Polymers using Conti
 nuous Flow Processing - Christian H. Hornung\, CSIRO Manufacturing\, Bayvi
 ew Avenue\, Clayton\, Victoria 3168\, Australia.
DTSTART:20160408T130000Z
DTEND:20160408T140000Z
UID:TALK65397@talks.cam.ac.uk
CONTACT:Vanessa Blake
DESCRIPTION:In recent years microreactor technology has transformed the wa
 y chemical synthesis is conducted in research laboratories by replacing ba
 tch reactions classically carried out in laboratory glassware\, with conti
 nuous flow processes using tubular or chip based reactor designs. A contin
 uous flow reactor can offer a range of benefits over batch processing\; as
  one example\, flow reactors have better heat and mass transfer properties
 \, leading to increased control over the process\, and often to improvemen
 ts in product quality. Our group at CSIRO engages with a series of compani
 es in the manufacturing sector on a broad range of commercial projects. We
  are focusing on the utilization of micro- and meso-structured continuous 
 flow reactors for applications in the pharmaceuticals\, fine chemicals\, p
 olymers\, flavours and fragrances industries as well as for the synthesis 
 of chemicals from renewable sources. Our aim is to optimise yield\, conver
 sion and the selectivity of chemical reactions\, cut process times\, minim
 ise process waste streams\, and reduce footprint of the reactor infrastruc
 ture by intensifying the chemical process through smart continuous reactor
  technology. One application our group has worked on intensively over the 
 past years is the use of continuous flow reactors for exothermic solution 
 phase polymerization reactions\, including the Reversible Addition-Fragmen
 tation chain Transfer (RAFT) process\;1-4 a convenient and versatile appro
 ach to control radical polymerisations invented by CSIRO.5 Other commercia
 l projects include the industrial manufacture of active pharmaceutical ing
 redients\, the synthesis of photochromic dyes and the production of fine c
 hemicals from refined sugars.6\n \nIn January 2016 the Australian Centre f
 or Industrial Flow Chemistry was established as a platform providing acces
 s to CSIRO’s cutting-edge research into industrial processing for Austra
 lian and international chemical manufacturers. The centre’s facilities o
 perate state-of-the-art flow chemistry reactor technology for development 
 and optimisation of chemical processes from discovery stage in the laborat
 ory to process scale-up in the pilot plant. Its focus lies on engagement w
 ith chemical manufacturers\, providing a range of services\, which include
 : a) process R&D operations at CSIRO\, b) managing the technology transfer
  to the client’s site\, c) as well as in-house training for industrial c
 ollaborators on the centre’s flow chemistry and process equipment.\n\nRe
 ferences:\n# C. H. Hornung et al.\, Org. Process Res. Dev. 2011\, 15\, 593
 .\n# C. H. Hornung\, X. Nguyen\, G. Dumsday\, S. Saubern\, Macromol. React
 . Eng. 2012\, 6\, 458.\n# N. Micic\, A. Young\, J. Rosselgong\, C. H. Horn
 ung\, Processes 2013\, 2\, 58.\n# C. H. Hornung\, X. Nguyen\, S. Kyi\, J. 
 Chiefari\, S. Saubern\, Aust. J. Chem. 2013\, 66\, 192.\n# J. Chiefari et 
 al.\, Macromolecules 1998\, 31\, 5559.\n# M. Brasholz\, K. von Känel\, C.
  H. Hornung\, S. Saubern\, J. Tsanaktsidis\, Green Chem. 2011\, 13\, 1114.
 \n\n
LOCATION:Lecture Theatre 1\, Department of Chemical Engineering  and Biote
 chnology\, New Museums Site
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