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SUMMARY:Gene-drug interaction screens in cancer - Sebastian Nijman (Ludwig
  Institute for Cancer Research Oxford)
DTSTART:20160516T150000Z
DTEND:20160516T160000Z
UID:TALK65564@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:With the complete molecular characterization of the major canc
 er types in sight\, it is clear that only a minority of the cancer genes r
 epresent readily accessible drug targets. Furthermore\, mechanistic biomar
 kers that predict response to targeted therapies remain scant. We employ l
 arge-scale chemical genetic screens in isogenic cells to systematically un
 cover gene-drug interactions in cancer. In this seminar\, I will present r
 ecently published and unpublished work uncovering unexpected gene-drug int
 eractions with potential clinical relevance. I will also present our recen
 t efforts to employ systematic reverse genetic screens using high throughp
 ut RNA-seq in arrayed collections of CRISPR/Cas9 edited cell lines.\n
LOCATION:CRUK CI Room 215A/B
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