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SUMMARY:Engineering structure and response of soft materials with DNA-medi
 ated interactions - Lorenzo Di Michele\, BSS Group\, Cavendish Laboratory
DTSTART:20160428T150000Z
DTEND:20160428T160000Z
UID:TALK65606@talks.cam.ac.uk
CONTACT:Stephen Walley
DESCRIPTION:The selectivity of Watson-Crick base pairing makes DNA the ide
 al tool for controlling structure and functionality at the nano and micro-
 scale.\nFirst\, I will give a brief review of basic ideas and recent advan
 ces in the booming field of DNA nanotechnology. \nI will then explain how 
 short synthetic DNA tethers can be used as artificial ligand/receptors to 
 drive the self-assembly of colloidal particles into materials with a uniqu
 e structure [1\,2\,3]. \nFinally I will demonstrate how these artificial l
 inkers can be coupled to compliant “particles”\, namely lipid vesicles
 \, to achieve a whole range of structural responses that cannot be induced
  using solid particles [4\,5\,6].\n\n[1] F. Varrato\, L. Di Michele\, M. B
 elushkin\, N. Dorsaz\, S. H. Nathan\, E. Eiser and G. Foffi\, Arrested Dem
 ixing Opens Route to Bigels\, Proc. Natl. Acad. Sci. USA\, 109(47) 19155-1
 9160\, (2012)\n\n[2] L. Di Michele\, F. Varrato\, J. Kotar\, S. H. Nathan\
 , G. Foffi and E. Eiser\, Multistep Kinetic Self-Assembly of DNA-coated Co
 lloids\, Nature Comm.\, 4:2007\, (2013)\n\n[3] L. Di Michele\, D. Fiocco\,
  F. Varrato\, S. Sastry\, E. Eiser\, and G. Foffi\, Aggregation Dynamics\,
  Structure\, and Mechanical Properties of Bigels\, Soft Matter\, 10 3633-3
 648\, (2014)\n\n[4] L. Parolini\, B. M. Mognetti\, J. Kotar\, E. Eiser\, P
 . Cicuta\, and L. Di Michele\, Volume and Porosity Thermal Regulation in L
 ipid Mesophases by Coupling Mobile Ligands to Soft Membranes\, Nature. Com
 m.\, 6:5948\, (2015)\n\n[5] S. F. Shimobayashi\, B. M. Mognetti\, L. Parol
 ini\, D. Orsi\, P. Cicuta\, and L. Di Michele\, Direct measurement of DNA-
 mediated adhesion between lipid bilayers\, Phys. Chem. Chem. Phys.\, 15(9)
  3115-3129\, (2015)\n\n[6] L. Parolini\, J. Kotar\, L. Di Michele*\, and B
 . M. Mognetti*\, Controlling Self-Assembly Kinetics of DNA-Functionalized 
 Liposomes Using Toehold Exchange Mechanism\, ACS Nano\, 10(2)\, 2392-2398\
 , (2016)
LOCATION:Mott Seminar Room\, Cavendish Laboratory
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