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SUMMARY:New mechanisms of inflammasome activation - Dr Alessandra Mortella
 ro\, Singapore Immunology Network
DTSTART:20160630T120000Z
DTEND:20160630T130000Z
UID:TALK65874@talks.cam.ac.uk
CONTACT:Katja Kivinen
DESCRIPTION:The nucleotide-binding oligomerization domain\, leucine-rich r
 epeat and pyrin domain containing (NLRP) family is an important group of i
 ntracellular pattern recognition receptors. Some members of this family ca
 n form large cytosolic protein complexes termed ‘inflammasomes’ that p
 romote caspase-1-mediated release of IL-1-beta and IL-18\, as well as the 
 inflammatory cell death known as pyriptosis. \n\nNLRP3\, also known as cry
 opyrin or NALP3\, is one of the best-characterized NLRP family members. NL
 RP3 inflammasome is an important intracellular sensor of microbial pathoge
 ns and stress signals. Studies using targeted disruption of NLRP3 have rev
 ealed key roles for this inflammasome in innate immunity and inflammation\
 , as well as in autoimmune diseases\, metabolic disorders\, and cancers. I
  will present our recent progress in understanding the mechanisms underlyi
 ng inflammation mediated by NLRP3 inflammasome in mice and in humans.
LOCATION:Lecture Theatre 2\, Clinical School\, Addenbrooke's Hospital
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