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SUMMARY:Universality in the clonal dynamics in developing tissues - Dr. St
 effen Rulands (University of Cambridge)
DTSTART:20160428T110000Z
DTEND:20160428T120000Z
UID:TALK65951@talks.cam.ac.uk
CONTACT:Salvatore Tesoro
DESCRIPTION:The self-organisation of cells during the development and main
 tenance of tissues is one of the most intriguing non-equilibrium processes
  in nature. How do stem and progenitor cells coordinate their behaviour in
  order to build a complex structure like a living organism? In recent year
 s lineage tracing experiments have become increasingly successful in unvei
 ling stem cell behaviour in adult tissues. However\, in development and tu
 mour growth its application remains a major problem. Due to cell dispersal
  or mechanical deformations labelled clones often fragment or merge\, maki
 ng the retrospective analysis of lineages highly ambiguous. What can we le
 arn from lineage tracing experiments in developing tissues?\n\nUsing the e
 xample of mammalian heart development we explore whether and how informati
 on on cell fate behaviour can be recovered from the analysis of lineage tr
 acing assays in developing tissues. By formally mapping the clonal dynamic
 s to the theory of aerosols and employing renormalisation group methods we
  show that fragmentation and merging lead to universal scaling distributio
 ns\, compromising and even erasing information on cell fate behaviour. As 
 well as providing a framework for distilling cell fate-specific informatio
 n from universal dependences at long times\, this study serves as a paradi
 gm for how the cellular dynamics of living tissues provides a laboratory f
 or statistical physics.\n
LOCATION:TCM Seminar room\, 530 Mott building
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