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SUMMARY:Congenital pain insensitivity - novel mutations - Samiha Shaikh
DTSTART:20160524T193000Z
DTEND:20160524T200000Z
UID:TALK65972@talks.cam.ac.uk
CONTACT:Michael Kosicki
DESCRIPTION:Pain is the unpleasant physical feeling which occurs during ti
 ssue damage. Pain is an important physiological protective mechanism that 
 is essential for the detection and prevention of contact with noxious stim
 uli as shown by its presence in animals diverse as snails\, reptiles and m
 ammals. Such noxious stimuli are detected by specialized sensory neurons c
 alled nociceptors. SCN9A encodes the sodium channel Na v 1.7 that is expre
 ssed at high densities on nociceptors. Recent genetic studies have identif
 ied this channel to underlie a the disorders primary erythermalgia and con
 genital insensitivity to pain. These conditions are\ncharacterized by very
  different pain phenotypes. Remarkably recent work has shown that these di
 sorders are caused by mutation in the same Na v 1.7 channel. These discove
 ries allow better understanding of the molecular mechanism of pain.
LOCATION:Senior Parlour\, Gonville and Caius College
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