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SUMMARY: ** CANCELLED** Functional versatility and regulation of proteins 
 with intrinsically disordered regions - M. Madan Babu\, MRC Laboratory of 
 Molecular Biology\, Cambridge\, UK
DTSTART:20160427T093000Z
DTEND:20160427T103000Z
UID:TALK65977@talks.cam.ac.uk
CONTACT:Jerome Charmet
DESCRIPTION:In the 1960s\, Christian Anfinsen postulated that the unique t
 hree-dimensional structure of a protein is determined by its amino acid se
 quence. This work laid the foundation for the sequence-structure-function 
 paradigm\, i.e. the sequence of a protein determines its structure\, and s
 tructure determines function. However\, a class of polypeptide segments ca
 lled Intrinsically Disordered Regions (IDRs) defies this postulate. In thi
 s presentation\, I will first describe established and emerging ideas abou
 t how disordered regions contribute to protein function. I will then discu
 ss molecular principles of how regulatory mechanisms such as alternative s
 plicing and asymmetric mRNA localization of transcripts encoding disordere
 d segments can increase the functional versatility of proteins. Finally\, 
 I will discuss how disordered regions contribute to human disease and the 
 emergence of cellular complexity during organismal evolution.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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