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SUMMARY:Sex chromosomes in development and disease - James Turner (The Fra
 ncis Crick Institute)
DTSTART:20160613T150000Z
DTEND:20160613T160000Z
UID:TALK66023@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:Males and females differ fundamentally in their sex chromosome
  make-up: females have two X chromosomes (XX)\, while males have one X chr
 omosome and one Y chromosome (XY). The sex chromosomes have a predominant 
 role in the formation of germ cells\, but also influence male-female diffe
 rences in growth\, behaviour and susceptibility to a variety of diseases\,
  e.g. hypertension and cancer. Furthermore\, the imbalance in dosage for X
  genes between females and males presents unique challenges for the develo
 ping embryo that are overcome by X chromosome inactivation - the silencing
  of one X chromosome in each female cell. \n\nOur lab studies the epigenet
 ics\, evolution and cell biology of the sex chromosomes from a variety of 
 organisms\, including mammals\, in order to understand how these chromosom
 es influence human health and disease. \n\nI will describe our recent find
 ings relating to these diverse aspects of sex chromosome biology.
LOCATION:CRUK CI Room 215A
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