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SUMMARY:A role for circadian rhythms in maintaining neuronal properties - 
 Timothy O'Leary
DTSTART:20160510T100000Z
DTEND:20160510T110000Z
UID:TALK66179@talks.cam.ac.uk
CONTACT:dw304
DESCRIPTION:Circadian rhythms cause dramatic\, daily oscillations in the s
 tate of the nervous system from the level of gene expression to network ac
 tivity. At the same time\, there are well known feedback mechanisms that m
 aintain activity and network properties\, permitting stable function in th
 e face of fluctuations due to sensory experience\, ongoing plasticity and 
 biological noise. Reconciling circadian oscillations with ongoing ‘homeo
 static’ regulation is therefore a challenge\, and one that is mysterious
 ly overlooked both theoretically and experimentally. I will present a simp
 le result that shows how large\, regular oscillations in the expression of
  ion channels and receptors in neurons can stabilize neuronal properties t
 hat would otherwise degrade under the control of activity-dependent feedba
 ck alone.\n
LOCATION:Engineering Department\, CBL Room 438
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