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SUMMARY:Order disorder transitions in the regulation of transcription: bio
 medical implications - Xavier Salvatella\, IRB Barcelona
DTSTART:20160511T093000Z
DTEND:20160511T103000Z
UID:TALK66187@talks.cam.ac.uk
CONTACT:Jerome Charmet
DESCRIPTION:The initiation of gene expression relies on transient protein 
 protein interactions between the transactivation domains of transcription 
 factors and the basal transcription machinery. Such transactivation domain
 s are in general intrinsically disordered and their affinity for the trans
 cription machinery and\, as a consequence\, their ability to activate tran
 scription can be modulated by changes in their propensity to adopt seconda
 ry structure as well as by post translational modifications. In my laborat
 ory we are very interested in understanding how the transcription factor a
 ndrogen receptor activates transcription because inhibiting this process r
 epresents a powerful therapeutic approach to halt the progression of prost
 ate cancer that has become refractory to hormone therapy\, the first line 
 treatment for this disease. In my talk I will present our current understa
 nding of this topic\, which we have obtained by using nuclear magnetic res
 onance as well as cell biology techniques.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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