BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Talks.cam//talks.cam.ac.uk// X-WR-CALNAME:Talks.cam BEGIN:VEVENT SUMMARY:New trends in cardiac valve and cardiovascular modelling - Prof Mi chael Sacks\, University of Texas at Austin DTSTART:20160603T130000Z DTEND:20160603T143000Z UID:TALK66229@talks.cam.ac.uk CONTACT:Katja Kivinen DESCRIPTION:Our Center has pioneered the development and application of mo rphologically-driven constitutive models for heart valve tissues. Our cur rent work focuses on mitral valve (MV) repair\, since recent long-term stu dies have indicated that excessive tissue stress and the resulting strain- induced tissue failure are important etiologic factors leading to the recu rrence of significant MR after repair. \n\nIn the present work\, we have d eveloped a high-fidelity computational framework\, incorporating detailed collagen fiber architecture\, accurate constitutive models for soft valve tissues\, and micro-anatomically accurate valvular geometry\, for simulati ons of functional mitral valves which allows us to investigate the organ-l evel mechanical responses due to physiological loadings. This computationa l tool also provides a means\, with some extension in the future\, to help the understanding of the connection between the repair-induced altered st resses/strains and valve functions\, and ultimately to aid in the optimal design of MV repair procedure with better performance and durability. \n\n We are also extending these in two directions. First\, we are extending t hese studies to cellular deformation to link with the underlying mechanobi ological responses of the constituent cellular population. Second\, we see k to incorporate the entire MV model into a ventricular model\, which is e ssential for the understanding of the underlying processes of ventricular\ , and MV coupled dysfunction. Other related projects on cardiac tissue re modeling and engineered tissue will be presented. LOCATION:Clinical School Seminar Room 5\, Addenbrooke's Hospital END:VEVENT END:VCALENDAR