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SUMMARY:The cutting edge of Alzheimer’s disease research - Prof. Bart De
  Strooper\,  University of Leuven and University College London
DTSTART:20160601T093000Z
DTEND:20160601T103000Z
UID:TALK66418@talks.cam.ac.uk
CONTACT:Jerome Charmet
DESCRIPTION:Alzheimer’s Disease is characterized by the progressive accu
 mulation of amyloid peptides in amyloid plaques and Tau peptides in neuron
 al tangles spread over the brain. This proteopathic stress induces a compl
 ex cascade of cellular reactions which leads over a period of several deca
 des to clinical dementia. The disease appears to be very difficult to mode
 l in non-primate species. In my seminar I will cover two topics. First I w
 ill speak about the proteases that are responsible for the initial generat
 ion of the amyloid peptide and how targeting them might yield preventative
  therapy for Alzheimer Disease. Second I will discuss a novel in vivo mode
 l for Alzheimer Disease. I will show how human neurons transplanted into a
  mouse brain loaded with amyloid peptide recapitulate important features o
 f the disease.\n \nRef:  De Strooper and Karran. The cellular phase of Alz
 heimer Disease\, Cell 2016.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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