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SUMMARY:Models of Microtubule Acetylation - Andrew Rutenberg (Dalhousie Un
 iversity)
DTSTART:20160621T130000Z
DTEND:20160621T134500Z
UID:TALK66533@talks.cam.ac.uk
CONTACT:INI IT
DESCRIPTION:Microtubule (MT) acetylation is done post-translationally in t
 he MT lumen by  the acetyltransferase alpha-TAT1. A simple picture is that
  alpha-TAT1 enters the  lumen at the open ends of MT\, and diffuses inside
  while acetylating.  Complicating this picture\, alpha-TAT1 is approximate
 ly half the luminal diameter  --- indicating that it may undergo single-fi
 le diffusion (SFD). Computationally\,  we explore the consequences of SFD 
 in this system. Experimentally\, in  collaboration with the group of Guill
 aume Montagnac (Institut Gustave Roussy)\,  immunofluorescence techniques 
 allows us to measure the acetylation pattern of  individual MT. We try to 
 reconcile the computational and experimental  approaches\, and highlight o
 pen questions.&nbsp\;
LOCATION:Seminar Room 1\, Newton Institute
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