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SUMMARY:Spatial simulation and analysis of actin filament dynamics and wav
 e propagation - Kevin Sanft (University of North Carolina )
DTSTART:20160621T134500Z
DTEND:20160621T143000Z
UID:TALK66534@talks.cam.ac.uk
CONTACT:INI IT
DESCRIPTION:<span>Co-authors: Hans Othmer (University of Minnesota)\,  You
 gan Cheng (University of Minnesota) <br></span> <span><br>Actin filaments 
 play an important role in many cellular processes\, including  cell motili
 ty. We present a stochastic model of actin filament dynamics in a  three-d
 imensional Cartesian domain. Actin monomers bind to nucleation sites on  t
 he membrane and polymerize to form filaments (F-actin). F-actin polymers  
 interact with membrane-bound nucleation promoting factors via a positive  
 feedback loop. The resulting model produces waves of actin filaments that 
  propagate along the membrane. Simulating polymer growth presents challeng
 es to  traditional Gillespie-type simulations. We describe a rule-based si
 mulation  approach to handle the many states of actin filament growth. Fin
 ally\, we discuss  techniques for managing the simulation output data.</sp
 an>
LOCATION:Seminar Room 1\, Newton Institute
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