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SUMMARY:Zebrafish as a model to understand development and disease - Ana L
 opez Ramirez and Helena Khaliullina (Department of Physiology\, Developmen
 t and Neuroscience)
DTSTART:20160720T173000Z
DTEND:20160720T190000Z
UID:TALK66747@talks.cam.ac.uk
CONTACT:Mark Dunning
DESCRIPTION: In the last few decades\, the use of zebrafish (Danio rerio) 
 as a model organism for scientific research has gained a lot of importance
 . Apart from studying developmental processes\, it is now being widely rec
 ognised as a great tool for modeling human diseases. The overwhelming homo
 logies between the human and zebrafish genomes allow direct studies of ori
 gins of neurodegeneration and disruptions in metabolism\, without ethical 
 concerns.\n\nIn this Masterclass\, we will present an overview of how zebr
 afish can be used to study a variety of diseases. First\, we will describe
  the study of neurodegenerative disorders\, characterised by the accumulat
 ion of Tau protein in the brain. Our aim is to characterise the effect of 
 a newly discovered mutation in the Tau protein and to evaluate how this mu
 tation affects protein degradation systems in neurons “in vivo”. In th
 e second part\, we will shed light on how the zebrafish retina can be util
 ised as a model for stem cell development. We investigate how environmenta
 l factors such as nutrition and oxygen availability affect stem cell prope
 rties and how disruption of stem cell metabolism can lead to malformations
  and cancer development.
LOCATION:Postdoc Centre\, 16 Mill Lane
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