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SUMMARY:Patronin/Shot cortical foci assemble the noncentrosomal microtubul
 e  array that specifies the Drosophila anterior-posterior axis - Dmitry Na
 shchekin (Gurdon Institute) 
DTSTART:20160706T163000Z
DTEND:20160706T183000Z
UID:TALK66797@talks.cam.ac.uk
CONTACT:Clara Sidor
DESCRIPTION:Patronin/Shot cortical foci assemble the noncentrosomal microt
 ubule  array that specifies the Drosophila anterior-posterior axis  A pola
 rised microtubule (MT) cytoskeleton plays an important role in establishin
 g and maintaining cell polarity. Even though centrosomes are commonly cons
 idered to be the main MT organising centers (MTOCs)\, in  many polarised c
 ells (e.g. epithelia\, neurons\, oocytes) centrosomes are inactivated and 
 most microtubules are of noncentrosomal origin. How such microtubules are 
 formed\, organised and regulated is still poorly understood. So far severa
 l noncentrosomal g-tubulin based pathways for  MT generation have been des
 cribed: Augmin/TPX2-dependent\, nuclear membrane-dependent and Golgi-depen
 dent. However\, their contribution to cell polarity is unclear. Here\, we 
 describe how the spectraplakin Shot  and the MT minus end-binding protein 
 Patronin form a new type of cortical noncentrosomal MTOCs (ncMTOCs) that w
 ork in a g-tubulin independent way  to assemble a polarised MT network in 
 the Drosophila oocyte.  Similar  ncMTOCs accumulate apically in epithelial
  cells\, where they are required for the formation of apical-basal microtu
 bule arrays. Thus\, Shot/Patronin  ncMTOCs may provide a general mechanism
  for organising noncentrosomal  microtubules in differentiated cells.
LOCATION:Gurdon Institute Tea Room
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