BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:The highs and lows of rotavirus vaccines\; why don’t they work a
 s well where they are needed most? - Prof Miren Iturriza-Gomara\, Institut
 e of Infection and global health\, Univeristy of Liverpool
DTSTART:20161130T160000Z
DTEND:20161130T170000Z
UID:TALK66893@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Gastroenteritis remains a leading cause of morbidity and morta
 lity worldwide and is the second commonest cause of death in young childre
 n in resource poor settings\, responsible for an estimated 578\, 000 death
 s in children under the age of five in 2013. The introduction of rotavirus
  vaccines in  has contributed to significant reductions in the burden of r
 otavirus diarrhoea\, and the number of   deaths in children <5 halved betw
 een 2000 and 2013. Despite their impact\, rotavirus vaccines are significa
 ntly less effective in children living in resource poor countries in Asia 
 and Africa\, where the majority of rotavirus deaths occur. The reasons for
  the poorer responses to rotavirus vaccines in low income countries are no
 t fully understood  but in addition to  the potential strain heterogeneity
  on differential efficacy\, various  host factors such as maternal antibod
 y\, age at vaccination\, endemicity of infections such as Malaria\, TB or 
 HIV\, persistent  exposure to enteric pathogens in the environment\,  alte
 red gut microbiota and malnutrition and micronutrient deficiencies all of 
 which are intimately interlinked and suspected  to impact  significantly i
 n the underperformance of rotavirus vaccines. In this talk I will summaris
 e some of the data on RV vaccine impact and current research aimed at unde
 rstanding the factors that may be responsible for their underperformance i
 n low income countries.  
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
END:VEVENT
END:VCALENDAR